ESTScan Detect coding regions in DNA sequences, even if they are of low quality
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detect coding DNA sequences detect coding regions correct sequencing errors ESTScan

ESTScan Description

Detect coding regions in DNA sequences, even if they are of low quality ESTScan project is a program that can detect coding regions in DNA sequences, even if they are of low quality. ESTScan will also detect and correct sequencing errors that lead to frameshifts.ESTScan is not a gene prediction program , nor is it an open reading frame detector. In fact, its strength lies in the fact that it does not require an open reading frame to detect a coding region. As a result, the program may miss a few translated amino acids at either the N or the C terminus, but will detect coding regions with high selectivity and sensitivity.MethodESTScan takes advantages of the bias in hexanucleotide usage found in coding regions relative to non-coding regions. This bias is formalized as an inhomogeneous 3-periodic fifth-order Hidden Markov Model (HMM). Additionally, the HMM of ESTScan has been extended to allows insertions and deletions when these improve the coding region statistics. What's New in This Release: · Add some sanity checks in the makesmat program, so that it doesn't crash on incorrect input and provides potentially useful error messages

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