MELTINGCompute the enthalpy and the entropy of the helix coil transition for a nucleic acid duplex | |
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- License:
- GPL
- Publisher Name:
- Nicolas Le Novère and Marine Dumousseau
- Operating Systems:
- Windows All
- File Size:
- 5.6 MB
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MELTING Description
MELTING is an open source application that was designed in order to provide you with a simple means of computing, for a nucleic acid duplex, the enthalpy and the entropy of the helix coil transition and afterwards the melting temperature. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program first computes the hybridisation enthalpy and entropy from the elementary parameters of each Crick's pair by the nearest-neighbor method. Then the melting temperature is computed. The set of thermodynamic parameters can be easely changed, for instance following an experimental breakthrough. MELTING 4 is written in ISO C and MELTING 5 in Java.
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